Although　tremendous　efforts　have　been　devoted　to　regulating　the　morphology　of　metal-organic　frameworks　(MOFs),　it　is　still　a　substantial　challenge　to　achieve　chirality　at　the　crystal　morphological　level.　This　work　presents　a　bottom-up　synthetic　approach　to　produce　chiral　morphological　bismuth-based　porphyrin　MOFs,　featuring　a　unique　surface　morphology　-　a　square　spiral　terrace-shaped　crystal　that　exhibits　mesoscopic　mirror-symmetry　breaking.　Compared　with　bulk　samples,　screw　dislocation　defects　could　promote　the　anisotropic　growth　of　the　square　spiral　terrace-shaped　nanoplates　under　conditions　of　low　supersaturation　concentrations　and　in　the　presence　of　polyvinyl　pyrrolidone　(PVP).　To　assess　the　effect　of　the　anisotropic　morphology　on　the　properties,　photocatalytic　hydrogen　peroxide　(H2O2)　production　experiments　under　pure　water　and　oxygen　conditions　(blue　LED　illumination,　λ　=　455　nm)　were　carried　out.　The　experimental　results　showed　that　the　screw　dislocation　nanoplates　displayed　1.5　times　higher　photocatalytic　activity　(156.22　μM　h−1)　than　that　of　bulk　samples　(106.24　μM　h−1).　This　may　be　attributed　to　the　better　dispersion　in　water　and　fully　exposed　catalytically　active　sites　of　the　screw　dislocation　nanoplates.　These　findings　provide　novel　insights　for　obtaining　MOFs　with　a　chiral　morphology　and　improving　the　photocatalytic　H2O2　generation　based　on　morphological　control.　©　2024　The　Royal　Society　of　Chemistry.