The　use　of　carbon　supports　in　direct　methanol　fuel　cells　easily　leads　to　the　shedding　and　poisoning　of　the　Pt　catalyst　and　hence　the　decrease　of　catalytic　activity.　Non-carbon　materials　have　been　studied　to　enhance　the　metal-support　interaction　and　the　catalytic　performance.　Herein,　we　explored　ultra-thin　CeO2　nanobelts　(2D-CeO2)　with　the　order-disorder　structure　as　the　support　of　the　PtCu　catalyst.　PtCu/2D-CeO2　shows　the　highest　current　density　of　37.24　mA　cm−2　toward　the　methanol　oxidation　reaction　(MOR),　and　a　limiting　current　density　of　4.82　mA　cm−2　towards　the　oxygen　reduction　reaction.　The　order-disorder　structure　of　2D-CeO2　generates　a　high　volume　of　oxygen　vacancies　and　strong　metal-support　interaction.　The　Pt0　proportion　of　PtCu/2D-CeO2　is　much　higher　than　that　of　PtCu/C　which　increases　the　active　sites.　The　d-band　center　of　PtCu　is　lowered　which　facilitates　the　adsorption　and　dissociation　of　reactants,　thereby　dramatically　boosting　the　electro-catalytic　performance.　©　2024　RSC.