Biomolecule　self-assembly　shows　great　potential　in　the　preparation　of　ordered　functional　materials.　Here,　we　prepare　a　gauzy　NC　material　via　water　guiding　guanine　biomolecule　self-assemble,　which　exhibits　the　better　ethylbenzene　conversion　(similar　to　50%),　styrene　selectivity　(similar　to　91%)　and　long-term　stability　(＞40　h)　in　ODH　of　ethylbenzene　to　styrene　than　that　of　guanine　solid　self-assembly　produced　NC　(38%　conversion　vs.　88%　selectivity)　sample.　The　study　shows　that　water　not　only　facilitates　guanine　biomolecule　self-assembly　to　form　more　stable　octamer　structure　but　restrains　vertical　growth　of　guanine,　and　resultant　NC-1000-12　h　holds　high　density　active　sites　and　outstanding　oxidation　resistance,　thus　enhancing　NC　catalytic　performance.　Overall,　current　work　provides　a　new　understanding　on　preparation　of　highly　efficient　NC　materials　through　supramolecular　self-assembly　strategy.