Cyclohexanone　is　a　key　raw　material　for　manufacturing　nylon　and　other　chemicals.　The　sustainable　conversion　of　biomass-derived　phenol　to　cyclohexanone　meets　the　requirements　of　sustainable　development　goal　but　still　be　challenging.　Herein,　a　catalyst　containing　isolated　Pd　cations　in　zeolite,　namely　Pd1/ZSM-5,　is　investigated　for　the　partial　hydrogenation　of　phenol　to　cyclohexanone.　Under　140　degrees　C　and　1.5　MPa　of　initial　hydrogen　pressure,　the　conversion　of　phenol　reaches　95.6%　with　the　selectivity　to　cyclohexanone　of　99.9%.　Besides,　the　turnover　rate　(TOR)　of　partial　hydrogenation　of　phenol　reaches　382.7　h-　1.　The　mild　adsorption　affinity　of　cyclohexanone　on　catalytic　sites　leads　to　the　high　selectivity.　Moreover,　as　unveiled　by　surface　reactivity　of　phenol　monitored　by　in-situ　infrared　spectrum,　the　oxygen　atom　of　phenol　hydroxyl　group　is　adsorbed　on　the　Bronsted　acid　site　of　Pd1/　ZSM-5　as　the　key　reaction　step.　The　reaction　intermediate　involves　the　partial　hydrogenation　of　benzene　ring　of　phenol.