The　powerful　adhesion　systems　of　marine　organisms　have　inspired　the　development　of　artificial　proteinbased　bioadhesives.　However,　achieving　robust　wet　adhesion　using　artificial　bioadhesives　remains　technically　challenging　because　the　key　element　of　liquid-liquid　phase　separation　(LLPS)-driven　complex　coacervation　in　natural　adhesion　systems　is　often　ignored.　In　this　study,　mimicking　the　complex　coacervation　phenomenon　of　marine　organisms,　an　artificial　protein-based　adhesive　hydrogel　(SFG　hydrogel)　was　developed　by　adopting　the　LLPS-mediated　coacervation　of　the　natural　protein　silk　fibroin　(SF)　and　the　anionic　surfactant　sodium　dodecylbenzene　sulfonate　(SDBS).　The　assembled　SF/SDBS　complex　coacervate　enabled　precise　spatial　positioning　and　easy　self-adjustable　deposition　on　irregular　substrate　surfaces,　allowing　for　tight　contact.　Spontaneous　liquid-to-solid　maturation　promoted　the　phase　transition　of　the　SF/SDBS　complex　coacervate　to　form　the　SFG　hydrogel　in　situ　,　enhancing　its　bulk　cohesiveness　and　interfacial　adhesion.　The　formed　SFG　hydrogel　exhibited　intrinsic　advantages　as　a　new　type　of　artificial　protein-based　adhesive,　including　good　biocompatibility,　robust　wet　adhesion,　rapid　blood-clotting　capacity,　and　easy　operation.　In　vitro　and　in　vivo　experiments　demonstrated　that　the　SFG　hydrogel　not　only　achieved　instant　and　effective　hemostatic　sealing　of　tissue　injuries　but　also　promoted　wound　healing　and　tissue　regeneration,　thus　advancing　its　clinical　applications.