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author:

Li, Zhiwei (Li, Zhiwei.) [1] | Liang, Hanji (Liang, Hanji.) [2] | Wang, Yabin (Wang, Yabin.) [3] | Zheng, Guodong (Zheng, Guodong.) [4] | Yang, Licong (Yang, Licong.) [5] (Scholars:杨丽聪)

Indexed by:

EI Scopus SCIE

Abstract:

The onset of Alzheimer's disease (AD) is significantly influenced by oxidative stress. Trace element selenium (Se) can be incorporated into selenoproteins to participate in redox regulation. In our previous study, it was found that brain-targeting chlorogenic acid-modified selenium nanoparticles (SeNPs) could effectively relieve oxidative stress in AD. However, the main mechanism of polyphenol-decorated SeNPs on antioxidant enzymes such as glutathione peroxidase is still unknown. Dihydromyricetin (DMY) is one polyphenol that has neuroprotective effects through antioxidant activities. In this study, chitosan (CS) was introduced as a stabilizer for the synthesis of a brain-targeted peptide (Tg: TGNYKALHPHNG) and DMY-modified SeNPs (Tg-CS/DMY@SeNPs). Tg-CS/DMY@SeNPs could improve the solubility of DMY and exhibited better free radical scavenging ability than DMY. Meanwhile, Tg-CS/DMY@SeNPs significantly enhanced the activity of antioxidant enzymes, which effectively inhibited ROS accumulation in A beta aggregate-induced PC12 cells. More importantly, Tg-CS/DMY@SeNPs could activate the Nrf2/Keap-1 signaling pathway to regulate the activity of antioxidant enzymes, especially selenophenase glutathione peroxidase in the brain and liver of APP/PS1 mice. In that case, Tg-CS/DMY@SeNPs also prevented oxidative damage-induced apoptosis by inhibiting the Caspase-3 signaling pathway in the brain and liver of APP/PS1 mice. Finally, Tg-CS/DMY@SeNPs remarkably improved cognitive disorders in the APP/PS1 mice. These results indicated that Tg-CS/DMY@SeNPs exhibited promising therapeutic effects in the antioxidant therapy of AD.

Keyword:

Alzheimer's disease antioxidant dihydromyricetin selenium nanoparticles selenoprotein

Community:

  • [ 1 ] [Li, Zhiwei]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 2 ] [Yang, Licong]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 3 ] [Li, Zhiwei]Jiangxi Agr Univ, Coll Food Sci & Engn, Jiangxi Key Lab Nat Prod & Funct Food, Nanchang 330045, Peoples R China
  • [ 4 ] [Liang, Hanji]Jiangxi Agr Univ, Coll Food Sci & Engn, Jiangxi Key Lab Nat Prod & Funct Food, Nanchang 330045, Peoples R China
  • [ 5 ] [Wang, Yabin]Jiangxi Agr Univ, Coll Food Sci & Engn, Jiangxi Key Lab Nat Prod & Funct Food, Nanchang 330045, Peoples R China
  • [ 6 ] [Zheng, Guodong]Jiangxi Agr Univ, Coll Food Sci & Engn, Jiangxi Key Lab Nat Prod & Funct Food, Nanchang 330045, Peoples R China

Reprint 's Address:

  • [Yang, Licong]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China;;[Zheng, Guodong]Jiangxi Agr Univ, Coll Food Sci & Engn, Jiangxi Key Lab Nat Prod & Funct Food, Nanchang 330045, Peoples R China;;

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Source :

ACS APPLIED NANO MATERIALS

Year: 2024

Issue: 17

Volume: 7

Page: 20411-20424

5 . 3 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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