Catalytic　hydrolysis　was　considered　as　an　efficient　technology　to　remove　carbonyl　sulfide　(COS).　The　introduction　of　oxygen　vacancy　(Ov)　is　a　promising　strategy　to　improve　the　catalytic　performance　of　COS　hydrolysis　by　promoting　the　adsorption　and　activation　of　reactants.　Herein,　we　reported　a　Cu-doped　TiO2　nanoflower　with　abundant　oxygen　vacancies　for　COS　hydrolysis.　The　Cu　species　successfully　entered　the　crystal　lattice　of　TiO2　and　induced　more　oxygen　vacancies　than　pure　TiO2.　The　Ov　sites　can　effectively　reduce　the　adsorption　and　activation　energy　of　COS　and　H2O.　Benefiting　from　the　ample　Ov　sites,　the　resulting　CuTiO2-8-F　achieved　nearly　100　%　COS　conversion　at　70　degrees　C　and　93.5　%　H2S　yield　at　130　degrees　C,　which　is　better　than　that　of　pure　TiO2.　Furthermore,　in　situ　FT-IR　measurements　and　density　functional　theory　(DFT)　calculations　were　performed　to　reveal　the　reaction　pathway　in　COS　hydrolysis.