Co-catalysts　are　commonly　employed　as　catalytic　centers　to　activate　reactants　and　intermediates　for　driving　redox　reactions　with　photogenerated　carriers　during　photocatalysis.　Herein,　a　group　of　electronically　inverted　perovskite-type　nitrides　CuxIn1-xNNi3　(0　＜=　x　＜=　1)　are　reported　as　novel　and　versatile　co-catalysts　for　the　significantly　enhanced　photocatalytic　hydrogen　production　performance　on　various　photocatalysts,　such　as　metal　sulfides　(CdS,　ZnIn2S4),　carbon　nitride　(g-C3N4),　and　metal　oxide　(TiO2),　respectively.　The　hybrid　photocatalyst　Cu0.5In0.5NNi3/CdS　exhibits　an　optimal　activity　up　to　6945　mu　mol　g-1　h-1　and　a　remarkable　enhancement　factor　of　6146%　compared　with　that　of　pristine　CdS.　Besides,　a　high　reaction　stability　with　repetitive　photocatalytic　cycles　is　achieved.　The　obvious　improvement　of　activity　can　be　ascribed　to　the　promoted　charge　separation　of　energetic　carriers　due　to　the　metallic　properties　of　CuxIn1-xNNi3　and　abundant　Ni　active　sites.　A　near-zero　Gibbs　free　energy　of　adsorbed　atomic　hydrogen　on　the　Ni-site　is　thermodynamically　favorable　for　hydrogen　evolution,　which　can　be　regulated　by　electronic　states　of　A-sites　(Cu/In).　This　work　not　only　demonstrates　the　great　potential　of　perovskite-structured　nitrides　as　a　universal　platform　for　enhanced　photocatalysis　but　also　addresses　the　importance　of　exploring　new　catalytic　applications　for　unique　perovskite-derivatives　with　cations/anions　exchanged　in　coordinated　sites　of　polyhedral.　For　the　first　time,　an　electronically　inverted　perovskite　CuxIn1-xNNi3　(0　＜=　x　＜=　1)　nitride　is　demonstrated　as　a　novel,　efficient,　robust,　and　universal　co-catalyst　for　significantly　enhanced　photocatalytic　hydrogen　production　on　various　widely　used　photocatalysts　(CdS,　ZnIn2S4,　TiO2,　and　g-C3N4),　with　enhancement　factors　of　activity　as　6146%,　327%,　1889%　and　450%,　respectively.　image