Currently,　the　research　on　wind-induced　response　of　membrane　structures　focuses　on　the　normal　wind　field,　and　there　is　little　research　on　typhoon　with　greater　disaster.　In　this　paper,　the　wind-induced　response　of　saddle　membrane　structures　under　typhoon　is　studied　by　numerical　simulation.　Firstly,　the　wind　field　information　of　typhoon　is　simulated　according　to　the　Weather　Research　and　Forecasting　model,　and　the　information　is　used　as　the　inlet　boundary　condition　of　Computational　Fluid　Dynamics.　The　vibration　modal　analysis　is　carried　out,　considering　the　influence　of　wind　field　intensity,　wind　direction　angle,　rise-span　ratio,　and　pretension　on　the　displacement　of　the　membrane.　The　results　show　that　the　probability　density　curve　of　wind-induced　response　has　a　certain　skewness.　The　saddle　membrane　structure　has　the　largest　vibration　amplitude　of　the　membrane　at　0　degrees　wind　direction　angle,　and　the　most　unfavorable　wind　pressure　value　of　the　membrane　is　negative.　In　reducing　the　displacement　of　the　membrane,　the　effect　of　reducing　the　wind-induced　vibration　response　by　increasing　the　rise-span　ratio　of　the　structure　is　better　than　that　of　the　pretension.　This　paper　reveals　that　the　law　of　wind-　induced　response　can　provide　a　theoretical　basis　for　the　design　of　membrane　structures　against　typhoons.