The　long-term　objective　of　tandem　reaction　is　to　investigate　‘intelligent’　tandem　reaction　systems　akin　to　living　cells.　Here　we＇ve　prepared　an　‘intelligent’　droplet　microreactor　for　the　tandem　reaction　using　droplet　microfluidic　technology　constructing　a　photoresponsive　microfluidic　tandem　reaction　system.　The　method　leverages　a　three-phase　emulsion＇s　‘two　membranes　and　three　phases’　structure　to　segregate　incompatible　reagents,　and　introduces　a　stimulating　surfactant　to　control　the　structure　of　this　emulsion　structure　for　intelligent　reaction　sequence　control,　enabling　efficient,　orderly　tandem　reaction　within　the　same　system.　Validating　this　concept,　we　applied　the　droplet　microreactor　to　the　condensation-reduction　cascade　reaction,　as　envisioned,　incompatible　condensation　and　reduction　reactions,　were　coordinated　by　cycling　the　UV　light　on　/off　for　a　smooth　cascade　reaction.　Compared　to　batch　reaction,　the　droplet　microreactor　showed　sixfold　catalytic　efficiency　enhancement　and　＞　99　%　reaction　selectivity.　Our　work　offers　novel　insights　into　realizing　intelligent　cascade　reactions.　©　2024