The　tension-compression　yield　asymmetry　caused　by　the　strengthening　of　Mg-Zn-Gd-Zr　alloy　due　to　extrusion　deformation　is　an　important　issue　that　must　be　addressed　in　its　application.　In　this　study,　the　effects　of　loading　direction　on　the　tensile　and　compressive　mechanical　behaviors　of　Mg-5Zn-2Gd-0.2Zr　alloy　were　systematically　investigated.　As　the　loading　angle　(the　angle　between　the　loading　direction　and　the　extrusion　direction)　increases　from　0　degrees　to　30　degrees,　45　degrees,　60　degrees　and　90　degrees,　the　tensile　yield　strength　decreases　more　significantly　than　the　compressive　yield　strength.　Consequently,　the　tension-compression　yield　asymmetry　is　gradually　improved.　Additionally,　the　ultimate　compressive　strength　decreases　more　markedly　than　the　ultimate　tensile　strength　with　the　increment　of　the　loading　angle.　In　tensile　tests　conducted　at　0　degrees,　30　degrees　and　45　degrees,　two　distinct　stages　of　decreasing　strain　hardening　rates　are　typically　observed.　For　the　60　degrees　and　90　degrees　tensile　tests,　one　unusual　ascending　stage　of　strain　hardening　rate　is　observed.　For　all　compressive　tests,　three　stages　of　strain　hardening　are　consistently　noted;　however,　the　increment　in　strain　hardening　rate　caused　by　{10-12}　extension　twinning　decreases　with　the　increasing　loading　angle.　A　model　combining　loading　angle　and　Schmid　factor　distribution　was　established.　The　calculated　results　indicate　that　the　dominant　deformation　modes　during　the　yielding　process　also　vary　significantly　with　the　loading　conditions.　This　clarification　highlights　the　differences　in　yield　strength　variations　between　tension　and　compression.　Finally,　an　analysis　of　the　plane　trace　and　crack　propagation　direction　near　the　fracture　surface　reveals　the　fracture　mechanisms　associated　with　tensile　and　compressive　tests　at　different　loading　directions.　This　study　promotes　understanding　of　the　mechanical　behaviors　of　Mg-5Zn-2Gd-0.2Zr　alloy　under　different　loading　directions,　and　helps　to　thoroughly　elucidate　the　anisotropic　effects　of　texture　on　the　mechanical　properties　of　magnesium　alloys.