Dealing　with　multiphase　systems　containing　solid　particles　in　microreactor　is　a　great　challenge.　Herein,　microreactor　with　coupled　oscillation　technology　was　designed　to　explore　clogging　mechanism.　The　simulation　revealed　that　no　vortex　was　generated　in　the　straight-tube　microreactor.　In　the　helical　microreactor,　the　vortex　could　be　generated　and　destroyed　periodically.　Second,　the　deposition　clogging　mechanism　was　explored.　Solid　particles　were　deposited　and　agglomerated　without　oscillation.　After　coupled　oscillation,　agglomerations　were　reduced,　but　deposition　still　existed　in　the　straight　microreactor.　In　the　helical　microreactor,　the　deposition　phenomenon　could　be　eliminated.　Finally,　the　bridging　clogging　mechanism　was　explored.　Solid　particles　were　deposited　first　and　then　bridged　without　oscillation,　forming　a　local　high　viscosity　zone,　and　eventually　completely　clogging　the　reactor.　After　coupled　oscillation,　it　was　difficult　to　destroy　the　bridging　behavior　in　the　straight　microreactor.　In　the　helical　microreactor,　the　periodic　vortex　could　effectively　destroy　the　bridging　structure　and　the　particles　flowed　uniformly.