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author:

Tian, Shaohua (Tian, Shaohua.) [1] | You, Lelan (You, Lelan.) [2] | Huang, Xu (Huang, Xu.) [3] | Liu, Chaoxiang (Liu, Chaoxiang.) [4] (Scholars:刘超翔) | Su, Jian-Qiang (Su, Jian-Qiang.) [5]

Indexed by:

EI Scopus SCIE

Abstract:

Sulfonamides are frequently detected with high concentrations in various environments and was regarded as a serious environmental risk by fostering the dissemination of antibiotic resistance genes. This study for the first time reported a strain SNF1 affiliated with Hydrogenophaga can efficiently degrade sulfamethoxazole (SMX). Strain SNF1 prefers growing under extra carbon sources and neutral condition, and could degrade 500 mg/L SMX completely within 16 h. Under the conditions optimized by response surface method (3.11 g/L NaAc, 0.77 g/L (NH4)2SO4, 4 ) 2 SO 4 , pH = 7.53, and T = 34.38 degree celsius), a high removal rate constant 0.5104 /h for 50 mg/L SMX was achieved. Coupling the intermediate products identification with comparative genomic analysis, a novel SMX degradation pathway was proposed. Unlike Actinomycetota degraders, SMX was deaminized and ring ortho-- hydroxylated in strain SNF1 using a Rieske dioxygenase in combination with glutamine synthetase system. Rieske dioxygenase gene expression was up-regulated by 1.09 to 6.02-fold in response to 100 mg/L SMX. When SMX is fully degraded, its antimicrobial activity drops by over 90 %, and its anticipated toxicity to aquatic organisms were overall reduced. These findings provided new insights into SMX-degrading microorganisms and mechanisms and highlighted the potential of Hydrogenophaga. sp. SNF1 for biological elimination of SMX from wastewater.

Keyword:

Biodegradation Co-metabolism Hydrogenophaga Sulfamethoxazole

Community:

  • [ 1 ] [Tian, Shaohua]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, 1799 Jimei Rd, Xiamen 361021, Peoples R China
  • [ 2 ] [You, Lelan]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, 1799 Jimei Rd, Xiamen 361021, Peoples R China
  • [ 3 ] [Huang, Xu]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, 1799 Jimei Rd, Xiamen 361021, Peoples R China
  • [ 4 ] [Su, Jian-Qiang]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, 1799 Jimei Rd, Xiamen 361021, Peoples R China
  • [ 5 ] [Tian, Shaohua]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
  • [ 6 ] [Huang, Xu]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
  • [ 7 ] [Su, Jian-Qiang]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
  • [ 8 ] [You, Lelan]Fuzhou Univ, Coll Environm & Safety Engn, Fuzhou 350108, Peoples R China
  • [ 9 ] [Liu, Chaoxiang]Fuzhou Univ, Coll Environm & Safety Engn, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Huang, Xu]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, 1799 Jimei Rd, Xiamen 361021, Peoples R China;;

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Source :

JOURNAL OF HAZARDOUS MATERIALS

ISSN: 0304-3894

Year: 2024

Volume: 480

1 2 . 2 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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