The　immune　system　plays　a　crucial　role　in　the　ageing　process.　As　individuals　age,　significant　alterations　in　the　immune　system　experiences　occur,　marked　by　a　decline　in　immune　cell　count,　compromised　immune　function,　and　decreased　immune　regulation　across　various　immune　organs.　These　changes　collectively　weaken　the　capacity　to　combat　diseases　and　infections,　highlighting　the　vulnerability　that　accompanies　ageing.　Exercise　is　a　potent　intervention　that　profoundly　influences　holistic　well-being　and　disease　mitigation,　with　a　notable　emphasis　on　immune　modulation.　In　general,　regular　moderate　exercise　holds　significant　potential　to　enhance　immune　defense　mechanisms　and　metabolic　well-being　by　augmenting　the　circulation　and　activation　of　immune　cells.　However,　some　exercise　modalities　would　trigger　detrimental　effects　on　the　immune　system.　It　can　be　seen　that　the　regulatory　responses　of　various　immune　organs　to　diverse　exercise　patterns　are　different.　This　review　aims　to　examine　the　immunological　responses　elicited　by　exercise　across　various　immune　organs,　including　the　lymph　nodes,　spleen,　bone　marrow,　and　thymus,　to　underscore　the　nuanced　interplay　between　exercise　patterns　and　the　immune　organ.　This　underscores　the　importance　of　customizing　exercise　interventions　to　optimize　immune　function　across　the　lifespan.　©　2024　Elsevier　B.V.