Selective Twin NIR-IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO-Mediated Oxidative Stress in Acute Liver Injury - Details

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Abstract：

Oxidative　stress,　orchestrated　by　myeloperoxidase　(MPO),　plays　crucial　roles in　the　progression　of　many　diseases.　Nonetheless,　the　role　of　MPO-mediated　oxidative　stress　in　distinct　factor-induced　acute　liver　injuries　(ALI)　is　still　up　for　dispute,　mainly　due　to　the　lack　of　probes　for　in　vivo　monitoring　of　MPO　releases.　Here,　a　highly　selective　MPO　probe　(CSQ)　based　on　the　epoxidation　biochemical　reaction　within　the　MPO-H2O2-Cl−　system　is　screened　to　construct　dual　near　infrared-IIb　(NIR-IIb) ratiometric　(F1550Em,　808Ex/F1550Em,　980Ex)　luminescence　nanoprobes　by　integrating　CSQ　onto　down　conversion　nanoparticles　(DCNPs)　with　and　without　liver-targeting　moiety　(twin　NIR-IIb　nanoprobes).　Liver-targeting　probes　are　employed　to　monitor　MPO　release,　whereas　non-liver-targeting　probes　are　utilized　to　assess　MPO　activity　across　all　cell　types.　Using　twin　NIR-IIb　nanoprobes,　the　MPO-mediated　oxidative　stress　progressively　increased　are　observed　in　carbon　tetrachloride　(CCl4)-induced　ALI　over　12 h.　In　contrast,　the　MPO-mediated　oxidative　stress　in　acetaminophen　(APAP)-induced　ALI　initially　increased,　peaked　within　3 h,　and　then　rapidly　weakened　to　normal　levels　within　12 h.　Importantly,　the　differential　release　of　MPO　from　neutrophils/Kupfer　cells　to　extracellular　fluids　in　the　two　types　of　ALI　is　revealed.　This　work　reveals　significant　differences　in　MPO　distribution　and　the　role　of　MPO-mediated　oxidative　stress　in　CCl4　and　APAP-induced　ALI.　©　2024　Wiley-VCH　GmbH.

Keyword：

APAP-induced liver injury CCl4-induced liver injury MPO-mediated oxidative stress NIR-IIb ratiometric luminescence imaging selective HOCl nanoprobe

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[ 1 ] [Liu X.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 2 ] [Liu X.]Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of MolecularCatalysis and Innovative Materials and iChem, Fudan University, Shanghai, 200433, China
[ 3 ] [Li W.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 4 ] [Li W.]School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, China
[ 5 ] [Shen Y.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 6 ] [He L.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 7 ] [Lai H.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 8 ] [Chen Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Chen L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Zhang X.-B.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[ 11 ] [Yuan L.]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

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Selective Twin NIR-IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO-Mediated Oxidative Stress in Acute Liver Injury
2024，ADVANCED FUNCTIONAL MATERIALS

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Advanced Functional Materials

ISSN： 1616-301X

Year： 2024

Issue： 6

Volume： 35

1 8 . 5 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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