The　healing　process　of　diabetic　foot　ulcers　is　challenging　due　to　the　presence　of　a　complex　and　severe　inflammatory　microenvironment,　characterized　by　hyperglycemia,　low　pH,　susceptibility　to　infection,　vascular　dysfunction,　and　over-expression　of　reactive　oxygen　species　(ROS),　which　can　potentially　lead　to　amputation　or　even　mortality.　Herein,　a　glucose　and　pH　dual-responsive　hydrogel　was　designed　and　prepared　by　crosslinking　phenylboronic　acid-grafted　quaternary　chitosan　(QF,　4　wt%)　with　dopamine-grafted　oxidized　hyaluronic　acid　(OD,　5　wt%)　through　phenylboronation,　schiff-base　reaction,　and　other　techniques.　The　multifunctional　QO/@PV@AB7　hydrogel　was　prepared　by　incorporating　pravastatin-loaded　chitosan　nanoparticles　(CSNPs@PV,　2　mg/mL)　and　antimicrobial　peptide　AMP-AB7　loaded　silica　nanoparticles　(SiO2NPs@AB7,　0.5　mg/mL).　The　results　demonstrate　that　the　QO/@PV@AB7　hydrogel　exhibits　good　responsiveness　to　acidic　conditions　and　high　glucose　levels,　while　effectively　scavenging　various　types　of　ROS.　Moreover,　it　exerted　protective　effects　against　oxidative　stress　on　cells,　enhanced　HUVECs　viability,　and　promoted　angiogenesis.　Notably,　the　QO/@PV@AB7　hydrogel　displayed　potent　antibacterial　activity　against　methicillin-resistant　Staphylococcus　aureus　(MRSA)　and　Escherichia　coli.　Additionally,　in　an　MRSA-infected　rat　model　of　diabetic　foot　wounds,　administration　of　the　QO/@PV@AB7　hydrogel　led　to　increased　secretion　of　pro-angiogenic　factors　such　as　vascular　endothelial　nitric　oxide　synthase　(eNOS),　vascular　endothelial-generating　factor　(VEGF),　and　endothelial　cell　adhesion　molecule　(CD31).　Furthermore,　the　hydrogel　significantly　reduced　the　levels　of　inflammatory　factors　such　as　interleukin-6　(IL-6)　and　tumor　necrosis　factor-α　(TNF-α),　while　simultaneously　increasing　the　levels　of　anti-inflammatory　cytokines　such　as　interleukin-10　(IL-10).　The　findings　suggest　that　multifunctional　hydrogels　incorporating　PV@CSNPs　and　SiO2NPs@AB7　demonstrate　promising　potential　as　a　therapeutic　approach　for　the　treatment　of　diabetic　foot.　Statement　of　Significance:　Here,　a　glucose　and　pH　dual-responsive　QO/@PV@AB7　hydrogel　with　antimicrobial　and　angiogenesis-promoting　properties　was　developed　for　the　treatment　of　infected　wounds　in　diabetic　feet.　Our　findings　demonstrate　that　the　proposed　hydrogel　exhibits　good　responsiveness,　effectively　scavenges　various　types　of　reactive　oxygen　species　(DPPH,　O2-,　-OH,　and　ABTS+),　provides　protection　against　oxidative　stress,　enhances　HUVECs　cell　viability,　and　promotes　angiogenesis.　Notably,　it　also　demonstrates　potent　antibacterial　activity　against　methicillin-resistant　Staphylococcus　aureus　(MRSA)　and　E.　coli.　Additionally,　in　vivo　experiments　demonstrated　that　the　hydrogel　exhibited　accelerated　wound　healing　in　MRSA-infected　diabetic　foot　ulcers,　with　a　reduction　of　four　days　compared　to　the　control　group.　©　2024　Acta　Materialia　Inc.