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author:

Hu, Ziwei (Hu, Ziwei.) [1] | Wang, Jianchao (Wang, Jianchao.) [2] | Gao, Qinquan (Gao, Qinquan.) [3] (Scholars:高钦泉) | Wu, Zhida (Wu, Zhida.) [4] | Xu, Hanchuan (Xu, Hanchuan.) [5] | Guo, Zhechen (Guo, Zhechen.) [6] | Quan, Jiawei (Quan, Jiawei.) [7] | Zhong, Lihua (Zhong, Lihua.) [8] | Du, Min (Du, Min.) [9] | Tong, Tong (Tong, Tong.) [10] (Scholars:童同) | Chen, Gang (Chen, Gang.) [11]

Indexed by:

EI Scopus SCIE

Abstract:

Pathological examination of nasopharyngeal carcinoma (NPC) is an indispensable factor for diagnosis, guiding clinical treatment and judging prognosis. Traditional and fully supervised NPC diagnosis algorithms require manual delineation of regions of interest on the gigapixel of whole slide images (WSIs), which however is laborious and often biased. In this paper, we propose a weakly supervised framework based on Tokens-to-Token Vision Transformer (WS-T2T-ViT) for accurate NPC classification with only a slide-level label. The label of tile images is inherited from their slide-level label. Specifically, WS-T2T-ViT is composed of the multi-resolution pyramid, T2T-ViT and multi-scale attention module. The multi-resolution pyramid is designed for imitating the coarse-to-fine process of manual pathological analysis to learn features from different magnification levels. The T2T module captures the local and global features to overcome the lack of global information. The multi-scale attention module improves classification performance by weighting the contributions of different granularity levels. Extensive experiments are performed on the 802-patient NPC and CAMELYON16 dataset. WS-T2T-ViT achieves an area under the receiver operating characteristic curve (AUC) of 0.989 for NPC classification on the NPC dataset. The experiment results of CAMELYON16 dataset demonstrate the robustness and generalizability of WS-T2T-ViT in WSI-level classification.

Keyword:

Annotations Breast cancer Cancer Digital pathology Feature extraction Hospitals image pyramid nasopharyngeal carcinoma transformer Transformers Tumors weakly supervised learning

Community:

  • [ 1 ] [Hu, Ziwei]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 2 ] [Gao, Qinquan]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 3 ] [Guo, Zhechen]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 4 ] [Quan, Jiawei]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 5 ] [Du, Min]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 6 ] [Tong, Tong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 7 ] [Wang, Jianchao]Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Clin Oncol Sch, Fuzhou 350014, Peoples R China
  • [ 8 ] [Wu, Zhida]Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Clin Oncol Sch, Fuzhou 350014, Peoples R China
  • [ 9 ] [Zhong, Lihua]Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Clin Oncol Sch, Fuzhou 350014, Peoples R China
  • [ 10 ] [Chen, Gang]Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Clin Oncol Sch, Fuzhou 350014, Peoples R China
  • [ 11 ] [Xu, Hanchuan]Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Dept Radiat Oncol, Fuzhou 350014, Peoples R China

Reprint 's Address:

  • 童同

    [Tong, Tong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China;;[Chen, Gang]Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Clin Oncol Sch, Fuzhou 350014, Peoples R China

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Source :

IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS

ISSN: 2168-2194

Year: 2024

Issue: 12

Volume: 28

Page: 7251-7262

6 . 7 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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