AimsThis　study　aims　to　explore　the　concept　of　future　orientation,　which　encompasses　individuals’　thoughts　about　the　future,　goal-setting,　planning,　response　to　challenges　and　behavioural　adjustments　in　evolving　situations.　Often　viewed　as　a　psychological　resource,　future　orientation　is　believed　to　be　developed　from　psychological　resilience.　The　study　investigates　the　curvilinear　relationship　between　childhood　maltreatment　and　future　orientation　while　examining　the　moderating　effects　of　genotype.MethodsA　total　of　14,675　Chinese　adults　self-reported　their　experiences　of　childhood　maltreatment　and　their　future　orientation.　The　influence　of　genetic　polymorphism　was　evaluated　through　genome-wide　interaction　studies　(GWIS;　genome-wide　association　study　[GWAS]　using　gene　×　environment　interaction)　and　a　candidate　genes　approach.ResultsBoth　GWAS　and　candidate　genes　analyses　consistently　indicated　that　rs4498771　and　its　linked　single-nucleotide　polymorphisms,　located　in　the　intergenic　area　surrounding　CSF3R,　significantly　interacted　with　early　trauma　to　influence　future　orientation.　Nonlinear　regression　analyses　identified　a　quadratic　or　cubic　association　between　future　orientation　and　childhood　maltreatment　across　some　genotypes.　Specifically,　as　levels　of　childhood　maltreatment　increased,　future　orientation　declined　for　all　genotypes.　However,　upon　reaching　a　certain　threshold,　future　orientation　exhibited　a　rebound　in　individuals　with　specific　genotypes.ConclusionsThe　findings　suggest　that　individuals　with　certain　genotypes　exhibit　greater　resilience　to　childhood　maltreatment.　Based　on　these　results,　we　propose　a　new　threshold　model　of　stress-related　growth.