Membrane　scaling　and　subsequent　membrane　wetting　pose　significant　impediments　to　the　application　of　membrane　distillation　(MD)　in　treating　high-salinity　wastewater.　This　study　introduces　an　innovative　in-situ　bubble　cleaning　strategy　for　the　amelioration　of　membrane　scaling　in　MD　processes.　A　catalytic　membrane　was　fabricated　by　introducing　MnO2　as　a　catalyst　by　electrospinning　and　the　self-cleaning　mechanism　involving　micro-nano　bubbles　and　superhydrophobic　surface　was　systematically　investigated.　Results　showed　that　the　fabricated　MnO2/PVDF　nanofiber　membranes　(M-FMP)　showed　superhydrophobic　properties,　with　a　water　contact　angle　and　rolling　angle　of　158°　and　17°,　which　significantly　improved　the　membrane＇s　resistance　to　wetting　and　fouling.　The　M-FMP　membrane　exhibited　exceptional　performance　across　ten　experimental　cycles,　achieving　a　flux　recovery　rate　of　over　92　%　and　demonstrating　robust　chemical　stability　following　repeated　cleanings　with　0.006　wt%　H2O2.　Notably,　CaSO4　deposition　on　the　M-FMP　membrane　was　approximately　46.0　μg/cm2,　accounting　for　only　14.6　%　of　the　deposition　observed　on　the　M-P　electrospun　membrane.　The　in-situ　cleaning　process　leveraging　micro-nano　bubbles　proved　to　be　significantly　more　effective　than　conventional　ex-situ　cleaning　methods,　offering　superior　performance　in　removing　scale　deposits.　Overall,　this　pioneering　in-situ　catalytic　self-cleaning　approach　offers　a　new　option　for　controlling　MD　membrane　scaling.　©　2024