Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Liao, W. (Liao, W..) [1] | Pan, Y. (Pan, Y..) [2] | Fu, J. (Fu, J..) [3] | Sun, X. (Sun, X..) [4] | Zhou, X. (Zhou, X..) [5] | Wang, M. (Wang, M..) [6] | Li, L. (Li, L..) [7] | Ren, L. (Ren, L..) [8]

Indexed by：

Scopus

Abstract：

Superoxide　anion　(O2•-)　is　a　highly　reactive　oxygen　species　(ROS)　within　tumor　cells,　and　its　abnormal　concentrations　can　lead　to　various　diseases　such　as　cancer,　inflammation,　and　premature　aging　disorders.　Here,　we　obtained　a　series　of　bioluminescence　resonance　energy　transfer　(BRET)　systems　that　can　be　used　for　sensitive　and　specific　detection　of　O2•-　by　varying　the　type　and　reaction　time　of　quantum　dots　(QDs)　and　combining　them　with　different　concentrations　of　recombinant　aequorin.　Among　them,　the　recombinant　aequorin-conjugated　CdTe/CdSe　QDs　had　the　highest　conjugation　efficiency　as　the　Aeq-QD　BRET　sensor,　which　has　a　remarkable　energy　transfer　efficiency　of　35.6%　and　an　extremely　low　limit　of　4　nM　for　detecting　O2•-,　which　exceeds　traditional　chemiluminescence　detection　relying　on　coelenterazine.　The　applicability　of　this　sensor　for　assessing　tumor　oxidative　stress　levels　was　also　validated　in　diverse　cell　types　and　cancer　mice.　This　study　effectively　contributes　to　the　field　of　cancer　research　and　tumor　oxidative　stress　biology　based　on　O2•-　sensing.　©　2024　American　Chemical　Society.

Keyword：

aequorin bioluminescence resonance energy transfer high selectivity high sensitivity quantum dots superoxide anion

Community：

  • [ 1 ] [Liao W.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 2 ] [Pan Y.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 3 ] [Fu J.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 4 ] [Sun X.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 5 ] [Zhou X.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 6 ] [Wang M.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China
  • [ 7 ] [Li L.]School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350116, China
  • [ 8 ] [Ren L.]Key Laboratory of Biomedical Engineering of Fujian Province University, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China

Reprint 's Address：

Email：

Show more details

Related Keywords：

Related Article：

Source ：

ACS Applied Bio Materials

ISSN： 2576-6422

Year： 2024

Issue： 12

Volume： 7

Page： 8709-8717

4 . 7 0 0

JCR@2023

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：1057/10827035
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1