Chiral　noncollinear　magnetic　nanostructures,　such　as　skyrmions,　are　intriguing　spin　configurations　with　significant　potential　for　magnetic　memory　technologies.　However,　the　limited　availability　of　2D　magnetic　materials　that　host　skyrmions　with　Curie　temperatures　above　room　temperature　presents　a　major　challenge　for　practical　implementation.　Chromium　tellurides　exhibit　diverse　spin　configurations　and　remarkable　stability　under　ambient　conditions,　making　them　a　promising　platform　for　fundamental　spin　physics　research　and　the　development　of　innovative　2D　spintronic　devices.　Here,　domain　structures　of　Cr0.85Te　nanoflakes　synthesized　via　chemical　vapor　deposition　are　investigated,　using　magnetic　force　microscopy　at　room　temperature.　The　results　reveal　that　the　domain　width　of　the　as-grown　nanoflakes　scales　with　the　square　root　of　their　thicknesses.　Notably,　the　emergence　and　annihilation　of　skyrmions　are　observed,　which　can　be　reversibly　controlled　by　external　magnetic　fields　and　thermal　excitation　in　ambient　air.　Micromagnetic　simulations　suggest　that　the　emergence　of　skyrmions　in　Cr0.85Te　nanoflakes　arises　from　inversion　symmetry　breaking　due　to　compositional　gradients　across　the　sample　thickness,　rather　than　the　interfacial　Dzyaloshinskii–Moriya　interaction.　These　findings　provide　new　insights　into　the　mechanisms　underlying　skyrmion　formation　in　2D　ferromagnets　and　open　exciting　possibilities　for　manipulating　domain　structures　at　room　temperature,　offering　practical　pathways　for　developing　next-generation　spintronic　devices.　©　2024　Wiley-VCH　GmbH.