Water　vapor　is　a　significant　component　in　real　volatile　organic　compounds　(VOCs)　exhaust　gas　and　has　a　considerable　impact　on　the　catalytic　performance　of　catalysts　for　VOC　oxidation.　Important　progress　has　been　made　in　the　reaction　mechanisms　of　H2O　and　water　resistance　strategies　for　VOC　oxidation　in　recent　years.　Despite　advancements　in　catalytic　technology,　most　catalysts　still　exhibit　low　activity　under　humid　conditions,　presenting　a　challenge　in　reducing　the　adverse　effects　of　H2O　on　VOC　oxidation.　To　develop　water-resistant　catalysts,　understanding　the　mechanistic　role　of　H2O　and　implementing　effective　water-resistance　strategies　with　influencing　factors　are　imperative.　This　Perspective　systematically　summarizes　related　research　on　the　impact　of　H2O　on　VOC　oxidation,　drawing　from　over　390　papers　published　between　2013　and　2024.　Five　main　influencing　factors　are　proposed　to　clarify　their　effects　on　the　role　of　H2O.　Five　inhibition/promotion　mechanisms　of　H2O　are　introduced,　elucidating　their　role　in　the　catalytic　oxidation　of　various　VOCs.　Additionally,　different　kinds　of　water　resistance　strategies　are　discussed,　including　the　fabrication　of　hydrophobic　materials,　the　design　of　specific　structures　and　morphologies,　and　the　introduction　of　additional　elements　for　catalyst　modification.　Finally,　scientific　challenges　and　opportunities　for　enhancing　the　design　of　efficient　and　water-resistant　catalysts　for　practical　applications　in　VOC　purification　are　highlighted.