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author:

Wang, Binhui (Wang, Binhui.) [1] | Zhu, Bin (Zhu, Bin.) [2] | Liu, Yihao (Liu, Yihao.) [3] | Ren, Bowen (Ren, Bowen.) [4] | Chen, Yurong (Chen, Yurong.) [5] | Feng, Luyao (Feng, Luyao.) [6] | Martin-Saldana, Sergio (Martin-Saldana, Sergio.) [7] | An, Bochen (An, Bochen.) [8] | Gong, Yining (Gong, Yining.) [9] | Ren, Yiming (Ren, Yiming.) [10] | Li, Jinqing (Li, Jinqing.) [11] | Huang, Da (Huang, Da.) [12] | Du, Baoju (Du, Baoju.) [13] | Liu, Jianheng (Liu, Jianheng.) [14] | Bu, Yazhong (Bu, Yazhong.) [15]

Indexed by:

EI

Abstract:

Shape memory cryogels hold immense promise for non-compressible hemostasis due to their shape recovery after contacting with blood. However, there is still a lack of an easy way to accelerate the shape-recovery speed which is highly associated with its performance. Meanwhile, the incorporation of extra pro-coagulation mechanisms will further improve the hemostatic efficacy. Herein, surfactant-stabilized bubbles are used to improve the shape-recovery speed of cryogels (GHP) through the modulation of porosity and pore size based on the capillary action. Additionally, 2D nanosheet vermiculite (VMT) is fabricated and incorporated into the system to get VMT@GHP cryogels. Remarkably, VMT@GHP exhibits a fast shape recovery speed (1.3 ± 0.3 s in the blood) among reported hemostats and the ability to promote blood coagulation. Animal studies show that VMT@GHP significantly accelerates the hemostasis in both rat and pig models, even in heparinized situations. In summary, VMT@GHP represents a highly effective solution for non-compressible hemorrhage control, with promising prospects for clinical translation. © 2024 Wiley-VCH GmbH.

Keyword:

Blood Coagulation Mammals Pore size

Community:

  • [ 1 ] [Wang, Binhui]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou; 350108, China
  • [ 2 ] [Wang, Binhui]Department of Burn/Plastic Surgery and Wound Repair, the Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an; 710061, China
  • [ 3 ] [Wang, Binhui]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 4 ] [Zhu, Bin]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 5 ] [Liu, Yihao]Department of Orthopedics, The Fourth Medical Centre of Chinese PLA General Hospital, Beijing; 100089, China
  • [ 6 ] [Liu, Yihao]Medical School of Chinese PLA, Beijing; 100853, China
  • [ 7 ] [Ren, Bowen]Department of Orthopedics, The Fourth Medical Centre of Chinese PLA General Hospital, Beijing; 100089, China
  • [ 8 ] [Ren, Bowen]Medical School of Chinese PLA, Beijing; 100853, China
  • [ 9 ] [Chen, Yurong]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 10 ] [Feng, Luyao]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 11 ] [Martin-Saldana, Sergio]POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia-San Sebastián; 20018, Spain
  • [ 12 ] [An, Bochen]Medical School of Chinese PLA, Beijing; 100853, China
  • [ 13 ] [Gong, Yining]Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an; 710054, China
  • [ 14 ] [Ren, Yiming]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 15 ] [Li, Jinqing]Department of Burn/Plastic Surgery and Wound Repair, the Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an; 710061, China
  • [ 16 ] [Huang, Da]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou; 350108, China
  • [ 17 ] [Du, Baoju]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China
  • [ 18 ] [Liu, Jianheng]Department of Orthopedics, The Fourth Medical Centre of Chinese PLA General Hospital, Beijing; 100089, China
  • [ 19 ] [Liu, Jianheng]Medical School of Chinese PLA, Beijing; 100853, China
  • [ 20 ] [Bu, Yazhong]Department of Burn/Plastic Surgery and Wound Repair, the Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an; 710061, China
  • [ 21 ] [Bu, Yazhong]Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an; 710061, China

Reprint 's Address:

  • [huang, da]college of biological science and engineering, fuzhou university, fujian, fuzhou; 350108, china;;

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Source :

Advanced Functional Materials

ISSN: 1616-301X

Year: 2025

Issue: 4

Volume: 35

1 8 . 5 0 0

JCR@2023

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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