Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Peng, S. (Peng, S..) [1] | Chen, Z. (Chen, Z..) [2] | Wang, J. (Wang, J..) [3] | Yu, M. (Yu, M..) [4] | Niu, X. (Niu, X..) [5] | Cui, T. (Cui, T..) [6] | Ao, R. (Ao, R..) [7] | Cai, H. (Cai, H..) [8] | Huang, H. (Huang, H..) [9] | Lin, L. (Lin, L..) [10] | Chen, X. (Chen, X..) [11] | Yang, H. (Yang, H..) [12]

Indexed by：

Scopus

Abstract：

Radiodynamic　therapy　that　employs　X-rays　to　trigger　localized　reactive　oxygen　species　(ROS)　generation　can　tackle　the　tissue　penetration　issue　of　phototherapy.　Although　calcium　tungstate　(CaWO4)　shows　great　potential　as　a　radiodynamic　agent　benefiting　from　its　strong　X-ray　absorption　and　the　ability　to　generate　electron–hole　(e−-h+)　pairs,　slow　charge　carrier　transfer　and　fast　e−-h+　recombination　greatly　limit　its　ROS-generating　performance.　Herein,　via　a　one-pot　wet-chemical　method,　oxygen　vacancy-rich　amorphous/crystalline　heterophase　CaWO4　nanoparticles　(Ov-a/c-CaWO4　NPs)　with　enhanced　radiodynamic　effect　are　synthesized　for　radiodynamic-immunotherapy　of　cancer.　The　phase　composition　and　oxygen　vacancy　content　of　CaWO4　can　be　easily　tuned　by　adjusting　the　solvothermal　temperature.　More　intriguingly,　the　amorphous/crystalline　interfaces　and　abundant　oxygen　vacancies　accelerate　charge　carrier　transfer　and　suppress　e−-h+　recombination,　respectively,　enabling　synergistically　improved　ROS　production　from　X-ray-irradiated　Ov-a/c-CaWO4　NPs.　In　addition　to　directly　inducing　oxidative　damage　of　cancer　cells,　radiodynamic　generation　of　ROS　also　boosts　immunogenic　cell　death　to　provoke　a　systemic　antitumor　immune　response,　thereby　allowing　the　inhibition　of　both　primary　and　distant　tumors　as　well　as　cancer　metastasis.　This　study　establishes　a　synergistic　enhancement　strategy　involving　the　integration　of　phase　and　defect　engineering　to　improve　the　ROS　generation　capacity　of　radiodynamic-immunotherapeutic　anticancer　nanoagents.　©　2024　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.

Keyword：

CaWO4 nanoparticles enhanced radiodynamic effect heterophase oxygen vacancies radiodynamic-immunotherapy

Community：

  • [ 1 ] [Peng S.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Chen Z.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 3 ] [Wang J.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Yu M.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 5 ] [Niu X.]Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China
  • [ 6 ] [Cui T.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore
  • [ 7 ] [Cui T.]Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore
  • [ 8 ] [Ao R.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 9 ] [Cai H.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 10 ] [Huang H.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 11 ] [Lin L.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 12 ] [Chen X.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore
  • [ 13 ] [Chen X.]Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore
  • [ 14 ] [Yang H.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

Email：

Show more details

Related Keywords：

Related Article：

Source ：

Advanced Science

ISSN： 2198-3844

Year： 2024

Issue： 7

Volume： 12

1 4 . 3 0 0

JCR@2023

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：148/10060039
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1