Catalyst-free coupling of peroxypyrroloindolenines with amines to afford stable peroxyindolenines - Details

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Zheng, X. (Zheng, X..) ^[1] | Wang, M. (Wang, M..) ^[2] | Sun, X. (Sun, X..) ^[3] | Gao, Y. (Gao, Y..) ^[4] | Chen, H. (Chen, H..) ^[5]

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Abstract：

Here　we　report　a　highly　efficient　method　for　coupling　of　peroxypyrroloindolenines　with　amines　under　catalyst-free　conditions　to　obtain　stable　C2-N　peroxyindolenines　in　high　yields　with　remarkable　functional　group　tolerance.　Initial　studies　have　shown　that　compound　13　exhibits　potent　inhibition　of　the　B16/F10　cell　line　with　an　IC50　value　of　2.18　μM.　©　2025　The　Royal　Society　of　Chemistry.

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[ 1 ] [Zheng X.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 2 ] [Wang M.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 3 ] [Sun X.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 4 ] [Gao Y.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 5 ] [Chen H.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China

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Organic and Biomolecular Chemistry

ISSN： 1477-0520

Year： 2024

2 . 9 0 0

JCR@2023

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