Objectives　This　study　aimed　to　examine　the　relationships　between　kinesiophobia　and　injury　severity,　balance　ability,　knee　pain　intensity,　self-efficacy,　and　functional　status　in　patients　with　meniscus　injuries　and　to　identify　key　predictors　of　kinesiophobia.　Design　A　single-center,　prospective　cross-sectional　study.　Methods　A　cross-sectional　study　involving　123　patients　diagnosed　with　meniscus　injuries　at　Fujian　Provincial　Hospital　was　conducted.　The　knee　range　of　motion　test　was　used　to　determine　limitations　in　knee　joint　mobility,　whereas　magnetic　resonance　imaging　(MRI)　was　used　to　assess　the　severity　of　meniscus　damage.　Several　validated　scales　were　administered:　the　Tampa　Scale　of　Kinesiophobia　(TSK-17)　to　measure　kinesiophobia,　the　visual　analog　scale　(VAS)　to　assess　pain　intensity,　the　general　self-efficacy　scale　(GSES)　to　evaluate　self-efficacy,　and　the　Lysholm　knee　score　(LKS)　to　assess　knee　functional　status.　Additionally,　balance　ability　was　assessed　using　the　Huber　360　Neuromuscular　Control　Training　and　Assessment　System　(DJO,　USA).　Spearman＇s　correlation　analysis　was　applied　to　explore　factors　associated　with　kinesiophobia,　whereas　simple　linear　regression　analysis　was　used　to　identify　its　predictors.　Results　Among　the　123　participants　included　in　the　study,　60.16%　were　identified　as　experiencing　kinesiophobia.　Among　these　participants,　69.10%　had　grade　III　meniscus　injuries,　and　33.3%　exhibited　limited　joint　movement.　The　key　clinical　characteristics　were　as　follows:　the　median　VAS　score　was　4　(IQR　2-6),　the　GSES　score　was　22　(IQR　20-29),　and　the　LKS　score　was　45　(IQR　38-55).　Kinesiophobia　was　significantly　correlated　with　injury　severity,　limited　joint　movement,　pain　intensity,　self-efficacy,　and　other　functional　parameters　(P　＜　0.05).　However,　no　significant　correlation　was　detected　between　kinesiophobia　and　limits　of　stability.　Simple　linear　regression　analysis　(R-2=0.917)　revealed　several　significant　predictors　of　kinesiophobia,　including　injury　severity　(beta　=　2.08),　pain　intensity　(beta　=　0.882),　Romberg　quotient　(RQ)　(beta　=　3.239),　and　limited　joint　movement　(beta　=　0.868).　In　contrast,　self-efficacy　(beta　=-0.455)　was　negatively　associated　with　kinesiophobia.　Furthermore,　Grade　III　injuries　and　RQ　were　found　to　be　associated　with　markedly　higher　levels　of　kinesiophobia.　Conclusion　Kinesiophobia　is　strongly　associated　with　knee　injury　severity,　limited　joint　movement,　RQ,　pain　intensity,　and　self-efficacy,　which　are　key　predictors.　Clinical　interventions　should　focus　on　these　factors　to　enhance　rehabilitation　outcomes.