The　development　of　green　and　easily　regulated　amphiphilic　particles　is　crucial　for　advancing　Pickering　emulsion　catalysis.　In　this　study,　lignin　particles　modified　via　sulfobutylation　were　employed　as　solid　emulsifiers　to　support　Pd　nanoparticles　(NPs),　thereby　enhancing　the　catalytic　efficiency　of　biphasic　reactions.　Sulfobutylation　of　lignin　effectively　adjusted　the　hydrophilic-hydrophobic　balance,　resulting　in　controlled　emulsion　types　and　droplet　sizes.　Pd　NPs　were　loaded　onto　lignin　with　a　50%　sulfobutylation　ratio　through　the　in　situ　reduction　of　active　functional　groups,　further　stabilized　by　the　cross-linked　network　structure　of　lignin.　In　the　hydrogenation　of　nitrobenzene,　the　Lig-50S-0.6Pd　catalyst　exhibited　superior　activity　compared　to　traditional　Pd/C　catalysts,　which　is　attributed　to　the　high　retention　of　active　sites　and　increased　interfacial　area.　This　work　underscores　the　potential　for　designing　lignin-based　amphiphilic　particles　and　developing　Pickering　emulsion-enhanced　reactions.　©　2025　American　Chemical　Society.