3,4-Difluoronitrobenzene　and　2,5-difluoronitrobenzene　are　significant　fine　chemical　intermediates,　widely　applied　in　the　fields　of　medicine,　pesticides,　and　liquid　crystal　materials,　particularly　in　pharmaceutical　production.　The　available　literature　on　their　thermodynamic　properties　is　scarce.　Thermophysical　property　measurements　for　pure　3,4-difluoronitrobenzene　and　2,5-difluoronitrobenzene　liquids　were　performed　in　relation　to　temperature:　density　(293.15　to　353.15)　K,　viscosity　(293.15　to　353.15)　K,　saturated　vapor　pressure　(366　to　478)　K.　Isobaric　vapor-liquid　equilibria　(VLE)　data　for　the　3,4-difluoronitrobenzene　and　2,5-difluoronitrobenzene　binary　system　were　experimentally　determined　at　101.2　kPa.　The　correspondence　between　density　and　temperature　was　successfully　modeled　utilizing　the　DIPPR　equation.　Meanwhile,　viscosity　data　were　analyzed　using　four　selected　equations,　with　VFT　equation　yielding　the　most　precise　results.　Furthermore,　the　correlation　between　saturated　vapor　pressure　and　temperature　can　be　precisely　established　using　Antoine　and　Riedel　equations.　The　binary　VLE　data　were　modeled　using　NRTL　and　Wilson　equations,　yielding　binary　interaction　parameters.　These　parameter-derived　predictions　closely　aligned　with　experimental　findings,　revealing　the　absence　of　azeotropic　behavior　in　the　binary　system.　The　thermophysical　properties　of　these　pure　components,　along　with　VLE　data　provided,　are　significant　for　the　separation　process　of　3,4-difluoronitrobenzene　and　2,5-difluoronitrobenzene.　©　2025　Elsevier　B.V.