Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging - Details

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Chemiluminescence　(CL)　is　a　self-illuminating　phenomenon　fueled　by　chemical　energy　instead　of　extra　excited　light,　which　features　superiority　in　sensitivity,　signal-to-background　ratios,　and　imaging　depth.　Strategies　to　synthesize　a　CL　emission　unimolecular　skeleton　in　the　second　near-infrared　window　(NIR-II)　and　a　unimolecular　probe　with　direct　duplex　NIR-II　[CL/fluorescence　(FL)]　emission　are　lacking.　Here,　we　employ　modular　synthesis　routes　to　construct　a　series　of　directly　activated　NIR-II　CL　emission　unimolecular　probes　with　a　maximum　emission　wavelength　of　up　to　1060　nm,　and　use　them　for　real-time　and　continuous　detection　of　the　superoxide　anion　generated　in　acetaminophen　induced　liver　injury　in　a　female　mice　model　under　both　NIR-II　CL　and　NIR-II　FL　imaging　channels.　Thus,　this　study　establishes　a　directly　activatable　NIR-II　CL　emission　unimolecular　skeleton,　validating　the　scalability　of　this　duplex　NIR-II　CL/FL　imaging　platform　in　bioactive　molecule　detection　and　disease　diagnosis.　©　The　Author(s)　2024.

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[ 1 ] [Chen Z.]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, China
[ 2 ] [Chen Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 3 ] [Chen Z.]Department School of Pharmacy, Anhui Medical University, Hefei, China
[ 4 ] [Li Q.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 5 ] [Wu Y.]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, China
[ 6 ] [Liu J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 7 ] [Liu L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 8 ] [Su L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 9 ] [Wu R.]MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, China
[ 10 ] [Song J.]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, China

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Nature Communications

ISSN： 2041-1723

Year： 2025

Issue： 1

Volume： 16

1 4 . 7 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 2

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