Molecular　electronics　represents　the　cutting-edge　and　interdisciplinary　effort　on　the　future　miniaturization　of　electronic　circuits.　Benefiting　from　synthetic　chemistry　and　theoretical　insights,　molecular　circuit　studies　have　promoted　devices　with　increasingly　complicated　structures.　Especially,　the　evolution　of　conductive　backbones　from　simple　chain-shaped　single-channel　configurations　to　complex　multi-channel　architectures　marks　a　pivotal　progression.　A　comprehensive　understanding　of　charge　transport　and　conductance　properties　in　multi-channel　molecular　devices　is　crucial　for　further　developing　molecular　circuits.　In　this　review,　we　provide　an　overview　of　conductance　properties,　categorizing　the　effect　on　conductance　into　enhancement　or　suppression.　The　underlying　mechanisms　of　conductance　modulation　are　discussed.　While　conductance　enhancement　is　attributed　to　factors　of　the　quantum-interference-based　superposition　law,　the　charge-induced　self-gating　effect,　and　the　facilitation　of　additional　conductive　channels　through　space-mediated　transport;　while　the　conductance　suppression　originates　from　the　destructive　quantum　interference　in　saturated　conductive　channels　and　the　“electron　selective　transport”　feature　within　multi-channel　structures　where　channels　converge　at　a　phenyl　group.　©　2025　Wiley-VCH　GmbH.