Modular synthesis of glycosyl sulfonamide via reductive coupling of glycosyl sulfinate and nitroarene - Details

author：

Indexed by：

Scopus

Abstract：

Glycosyl　sulfonamides　have　been　identified　as　novel　inhibitors　of　carbonic　anhydrase,　showing　great　potential　for　cancer　treatment.　However,　previous　approaches　to　synthesizing　glycosyl　sulfonamides　require　multi　steps,　resulting　in　low　efficiency　and　being　time-consuming.　Herein,　we　disclose　a　reductive　coupling　strategy　that　enables　the　modular　synthesis　of　glycosyl　sulfonamide　using　readily　accessible　glycosyl　sulfinates　and　feedstock　chemical　nitroarenes.　This　method　allows　for　the　construction　of　rarely　reported　N-aryl　glycosyl　sulfonamides　and　exhibits　tolerance　to　a　variety　of　functional　groups.　©　2025　The　Royal　Society　of　Chemistry.

Keyword：

Community：

[ 1 ] [Zhen W.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Ma J.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Ni Z.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Luo J.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Shen X.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Xie Y.]Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shangdong University, Jinan, 250012, China
[ 7 ] [Qiu H.]Institute of Mineral and Waste Processing, Recycling and Circular Economy Systems (IFAD), Clausthal University of Technology, Clausthal-Zellerfeld, 38678, Germany
[ 8 ] [Xu C.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Xu C.]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, CAS, Shanghai, 200032, China

Reprint 's Address：

Email：

Show more details

Related Keywords：

Source ：

New Journal of Chemistry

ISSN： 1144-0546

Year： 2025

Issue： 9

Volume： 49

Page： 3416-3421

2 . 7 0 0

JCR@2023

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to