This　study　investigates　the　environmental　significance　of　ciprofloxacin　as　an　emerging　contaminant　and　the　need　for　effective　degradation　methods.　The　chemical　coprecipitation　method　was　used　in　this　study　to　prepare　the　Zn-Cu-Ni　composite　silicate,　serving　as　a　heterogeneous　ozonation　catalyst.　The　catalytic　activity　was　then　evaluated　by　degrading　ciprofloxacin　(CIP).　Scanning　electron　microscopy,　X-ray　diffraction,　X-ray　photoelectron　spectroscopy,　nitrogen　adsorption–desorption,　and　Fourier　transform　infrared　analysis　(FTIR)　were　used　to　characterize　the　Zn-Cu-Ni　composite　silicate.　The　catalyst　had　a　high　surface　area　(308.137　m2/g),　no　regular　morphology,　and　a　particle　size　of　7.6　µm　and　contained　Si-O-Si,　Ni-O-Si,　and　Zn-O-Si.　The　results　showed　that　the　CIP　degradation　and　mineralization　rates　(pH　7.0,　CIP　3.0　mg/L,　Ozone　1.5　mg/L)　were　significantly　enhanced　in　the　presence　of　the　Zn-Cu-Ni　composite　silicate.　The　CIP　and　total　organic　carbon　(TOC)　removal　rates　were　increased　by　51.09%　and　18.72%,　respectively,　under　optimal　conditions,　compared　with　ozonation　alone.　The　adsorption　of　Zn-Cu-Ni　composite　silicate,　ozone　oxidation,　and　·OH　oxidation　synergistically　promoted　the　efficient　removal　of　CIP.　This　study　provides　valuable　catalytic　ozone　technology　for　degradation　of　antibiotics　in　wastewater　to　reduce　environmental　pollution　with　potential　practical　applications.　©　2025　by　the　authors.