Objective:　To　investigate　the　cellular　function　of　SOX18　in　nasopharyngeal　carcinoma　(NPC)　by　analyzing　its　effects　on　tumor　cell　proliferation,　apoptosis,　migration　and　invasion,　and　to　verify　its　expression　and　prognostic　significance　by　clinical　samples,　thereby　providing　a　basis　for　precise　diagnosis　and　treatment.　Methods:　SOX18　expression　was　analyzed　in　NPC　cell　lines　and　clinical　samples.　Gene　silencing　techniques　were　utilized　to　reduce　SOX18　expression　in　NPC　cells,　followed　by　assays　to　evaluate　cell　proliferation,　apoptosis,　migration,　and　invasion.　Additionally,　changes　in　the　Wnt/(3-catenin　signaling　pathway　were　examined.　Results:　High　SOX18　expression　was　correlated　with　poor　survival　in　NPC　patients.　Silencing　SOX18　significantly　inhibited　cell　proliferation,　increased　apoptosis,　and　suppressed　migration　and　invasion　capabilities.　Furthermore,　SOX18　silencing　downregulated　key　genes　and　proteins　associated　with　the　Wnt/(3-catenin　signaling　pathway.　Conclusion:　SOX18　plays　a　critical　role　in　NPC　progression　by　affecting　key　cellular　behaviors.　Targeting　SOX18　may　offer　new　therapeutic　strategies　and　improve　prognostic　assessments　for　NPC　patients,　highlighting　its　potential　as　a　valuable　molecular　marker　for　cancer　treatment.