Background:　The　prevalence　of　depression　among　patients　with　chronic　kidney　disease　(CKD)　is　high　and　closely　related　to　poor　prognosis.　However,　the　association　between　sleep　onset　time,　sleep　duration,　and　depression　in　CKD　patients　has　not　been　thoroughly　studied.　Methods:　This　study　utilized　cross-sectional　data　from　CKD　patients　who　participated　in　the　National　Health　and　Nutrition　Examination　Survey　from　2015　to　2020,　analyzing　their　sleep　onset　time,　sleep　duration,　and　Patient　Health　Questionnaire-Nine.　Logistic　regression　models　and　restricted　cubic　spline　models　were　used　to　explore　the　association　between　sleep　onset　time,　sleep　duration,　and　depression　in　CKD　patients.　Results:　A　total　of　2141　CKD　patients　aged　20　and　above　were　included　in　this　study,　among　whom　246　(11.5　%)　had　depression.　Compared　to　those　reporting　optimal　sleep　onset　(22:00-23:59)　and　sufficient　sleep　duration　(7-8　h),　CKD　patients　with　late　sleep　onset　(＞=　24:00)　and　either　insufficient　(＜7　h)　or　excessive　(＞=　9　h)　sleep　had　a　significantly　higher　risk　of　depression,　with　adjusted　OR　of　2.03　(95　%　CI:1.29-3.19)　and　2.07　(95　%　CI:1.07-4.00),　respectively.　Additionally,　the　association　between　sleep　onset　time,　sleep　duration,　and　depression　showed　a　U-shaped　pattern,　with　the　inflection　point　for　sleep　onset　time　at　23:00　and　for　sleep　duration　at　7.5　h.　Conclusion:　Inappropriate　sleep　onset　time　and　sleep　duration　are　significantly　associated　with　depression　in　CKD　patients.　This　association　may　be　important　to　consider　in　clinical　practice　for　the　prevention　and　management　of　depressive　symptoms　in　CKD　patients.