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author:

Lin, Min (Lin, Min.) [1] | Lin, Xiongbiao (Lin, Xiongbiao.) [2] | Chen, Wenwen (Chen, Wenwen.) [3] | Huang, Feng (Huang, Feng.) [4]

Indexed by:

SCIE

Abstract:

The "Life's Essential 8" (LE8) score is an assessment of cardiovascular health recently introduced by the American Heart Association. This study aimed to explore the correlation of the total LE8 score and its individual metrics with all-cause and cardiovascular disease (CVD) mortality in patients with hypertension. Data from 10,556 hypertension adults were retrieved from National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. After a median follow-up of 6.75 years, patients with high LE8 scores (>= 75 points) showed significantly lower mortality rates from all causes and CVD (P < 0.001). Cox regression analysis indicated that high LE8 scores were associated with a 40% lower risk of all-cause [0.60(0.50-0.73)] and CVD mortality [0.60(0.43-0.83)] compared to low scores. As the total LE8 score increased linearly, the likelihood of all-cause and CVD mortality decreased, with a potential threshold at 60 points. Subgroup analyses revealed that diet, sleep, nicotine exposure, physical activity, and blood glucose control affected both types of mortality. The LE8 score was negatively correlated with the risks of all-cause and CVD mortality in hypertensive patients. Life interventions and management of physical indicators based on the LE8 score may be an effective way to improve mortality in hypertensive patients.

Keyword:

Cardiovascular disease Hypertension Life's essential 8 Mortality NHANES

Community:

  • [ 1 ] [Lin, Min]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China
  • [ 2 ] [Chen, Wenwen]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China
  • [ 3 ] [Huang, Feng]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China
  • [ 4 ] [Lin, Xiongbiao]Xiamen Univ, Dept Electrocardiogram, Affiliated Hosp 1, Xiamen, Peoples R China
  • [ 5 ] [Huang, Feng]Fuzhou Univ, Affiliated Prov Hosp, Fuzhou, Peoples R China
  • [ 6 ] [Huang, Feng]Fujian Prov Inst Clin Geriatr, Fuzhou, Peoples R China
  • [ 7 ] [Huang, Feng]Fujian Key Lab Geriatr, Fuzhou, Peoples R China
  • [ 8 ] [Huang, Feng]Fujian Prov Ctr Geriatr, Fuzhou, Peoples R China

Reprint 's Address:

  • [Huang, Feng]Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China;;[Huang, Feng]Fuzhou Univ, Affiliated Prov Hosp, Fuzhou, Peoples R China;;[Huang, Feng]Fujian Prov Inst Clin Geriatr, Fuzhou, Peoples R China;;[Huang, Feng]Fujian Key Lab Geriatr, Fuzhou, Peoples R China;;[Huang, Feng]Fujian Prov Ctr Geriatr, Fuzhou, Peoples R China

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Source :

SCIENTIFIC REPORTS

ISSN: 2045-2322

Year: 2025

Issue: 1

Volume: 15

3 . 8 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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