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author:

Li, Xiaolan (Li, Xiaolan.) [1] | Lan, Huiyu (Lan, Huiyu.) [2] | Lin, Xinying (Lin, Xinying.) [3] | Huang, Huibin (Huang, Huibin.) [4] | Wen, Junping (Wen, Junping.) [5] | Chen, Gang (Chen, Gang.) [6] | Lin, Wei (Lin, Wei.) [7]

Indexed by:

SCIE

Abstract:

Background Increased detection of non-functioning adrenal incidentalomas (NFAI) due to widespread abdominal imaging may underestimate associated metabolic risks. To examine NFAI's impact on metabolic comorbidities and evaluate outcomes in surgical and non-surgical management, including changes in NFAI characteristics during follow-up. Methods Meta-analysis of studies from PubMed, Embase, Cochrane Library, and Web of Science (January 2000 to May 2024). Studies focusing on patients with serum cortisol levels <= 50 nmol/L after 1 mg dexamethasone suppression test (DST). Prevalence of hypertension, diabetes, obesity, and lipid disorders before and after follow-up. Tumor growth (> 10 mm increase) and functional changes (1 mg DST retest) were assessed. Results Eighteen studies met inclusion criteria (n = 2,059). In the non-surgical group, diabetes (RR: 1.33, 95% CI: 1.07-1.65) and lipid disorders (RR: 1.22, 95% CI: 1.07-1.38) increased significantly, while hypertension (RR: 1.07, 95% CI: 0.99-1.16) and obesity (RR: 1.05, 95% CI: 0.91-1.21) showed no significant change. Surgical intervention significantly improved hypertension (RR: 0.67, 95% CI: 0.52-0.86). During mean follow-up of 46.1 months, 4% (95% CI: 2%- 8%) of NFAI enlarged > 10 mm, while 8% (95% CI: 5%- 14%) became functional during 45.1 months of follow-up. Conclusions In patients with NFAI, subtle hormone secretion may exist despite current diagnostic criteria suggesting non-functionality. Such tumors show significant associations with metabolic disorders, particularly diabetes mellitus and dyslipidemia. Future research should focus on developing more sensitive diagnostic methods and establishing evidence-based surgical intervention criteria through prospective studies.

Keyword:

Adrenal incidentaloma (AI) Metabolic comorbidities Non-functioning adrenal incidentaloma Non-surgical management Surgical management

Community:

  • [ 1 ] [Li, Xiaolan]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 2 ] [Lan, Huiyu]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 3 ] [Lin, Xinying]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 4 ] [Huang, Huibin]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 5 ] [Wen, Junping]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 6 ] [Chen, Gang]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China
  • [ 7 ] [Lin, Wei]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China

Reprint 's Address:

  • 待查

    [Lin, Wei]Fuzhou Univ, Fujian Med Univ, Fujian Prov Hosp, Affiliated Prov Hosp,Dept Endocrinol,Shengli Clin, 134 Dongjie St, Fuzhou, Fujian, Peoples R China

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Source :

BMC ENDOCRINE DISORDERS

Year: 2025

Issue: 1

Volume: 25

2 . 8 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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