Construction of 2-(Trifluoromethyl)-[1,2,4]Triazolo[1,5-a]Quinoline Derivatives via Cycloaddition of N-Amino Quinolinium Salts with CF3CN - Details

author：

Chen, Zhezuo (Chen, Zhezuo.) ^[1] | Yang, Peiqi (Yang, Peiqi.) ^[2] | Chen, Shouxiong (Chen, Shouxiong.) ^[3] | Yang, Fafu (Yang, Fafu.) ^[4] | Weng, Zhiqiang (Weng, Zhiqiang.) ^[5]

Indexed by：

SCIE

Abstract：

A　(3+2)-cycloaddition　of　N-amino　quinolinium　salts　with　in　situ　generated　trifluoroacetonitrile　is　disclosed.　The　reaction　affords　access　to　structurally　diverse　2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]quinoline　derivatives　in　good　yields,　utilizing　2,2,2-trifluoroacetaldehyde　O-(aryl)oxime　as　precursor　of　trifluoroacetonitrile.

Keyword：

cycloaddition iminoquinolinium ylide triazoloquinoline trifluoroacetonitrile trifluoromethylation

Community：

[ 1 ] [Chen, Zhezuo]Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China
[ 2 ] [Yang, Peiqi]Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China
[ 3 ] [Yang, Fafu]Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China
[ 4 ] [Chen, Shouxiong]Minjiang Univ, Fujian Prov Univ, Coll Mat & Chem Engn, Engn Res Ctr Green Mat & Chem Engn, Fuzhou 350108, Peoples R China
[ 5 ] [Weng, Zhiqiang]Minjiang Univ, Fujian Prov Univ, Coll Mat & Chem Engn, Engn Res Ctr Green Mat & Chem Engn, Fuzhou 350108, Peoples R China
[ 6 ] [Chen, Shouxiong]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China
[ 7 ] [Weng, Zhiqiang]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China

Reprint 's Address：

[Yang, Fafu]Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China;;[Weng, Zhiqiang]Minjiang Univ, Fujian Prov Univ, Coll Mat & Chem Engn, Engn Res Ctr Green Mat & Chem Engn, Fuzhou 350108, Peoples R China;;[Weng, Zhiqiang]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China

Email：

yangfafu@fjnu.edu.cn |
zweng@mju.edu.cn

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