Background　Sepsis-related　adult　respiratory　distress　syndrome　(ARDS)　is　a　life-threatening　condition　characterised　by　a　high　mortality　rate.　This　underscores　the　pressing　requirement　to　identify　and　develop　potential　therapeutic　targets　for　the　severe　condition.　This　study　investigated　the　genetic　predisposition　to　sepsis-related　ARDS　in　this　study.　Methods　We　utilised　summary-based　Mendelian　randomisation　(SMR),　two-sample　MR　(TSMR),　mediating　MR,　and　multivariate　MR　(MVMR)　analysis　to　explore　the　genetic　susceptibility　of　sepsis-related　ARDS　by　integrating　over　10　000　cis-expression　quantitative　trait　loci　(cis-eQTLs)　and　over　100　000　participants.　Subsequently,　we　performed　drug　target　analysis　to　identify　potentially　druggable　cis-eQTL　genes.　Results　The　SMR　analysis　identified　677　cis-eQTL　genes　associated　with　sepsis.　Further　TSMR　validation　filtered　72　cis-eQTL　genes　causally　associated　with　sepsis.　Sepsis　was　causally　associated　with　ARDS　(beta　=　1.80,　standard　error　(SE)　=　0.36,　P　＜　0.001).　After　conducting　the　mediating　MR　and　MVMR　analysis,　50　cis-eQTL　genes　were　reported　to　be　causally　associated　with　sepsis-related　ARDS.　Subsequent　drug　target　analysis　confirmed　the　role　of　four　targets　(PSMA4,　PDK2,　RPS18,　and　NDUFV3)　as　druggable　genes　for　sepsis-related　ARDS.　Conclusions　Through　an　extensive　analysis,　we　identified　potential　drug　targets　for　sepsis-related　ARDS.　Additional　research　is　imperative　to　substantiate　our　discoveries　and　to　pave　the　way　for　the　development　of　novel　pharmaceuticals　aimed　at　these　specific　targets.