Objective　The　association　between　the　weight-adjusted　waist　index　(WWI)　and　age-related　macular　degeneration　(AMD)　in　US　adults　aged　40　years　and　older　is　unknown.　The　goal　of　this　study　was　to　ascertain　a　possible　association　between　the　two.　Methods　Data　were　obtained　from　the　National　Health　and　Nutrition　Examination　Survey　(NHANES)　in　the　US　from　2005　to　2008.　The　WWI　was　calculated　by　dividing　waist　circumference　(WC)　by　the　square　root　of　body　weight　(kg).　AMD　was　diagnosed　based　on　distinctive　features　observed　in　the　fundus,　using　a　standard　classification　system.　Weighted　logistic　regression　analyses　were　conducted　to　investigate　the　association　between　the　WWI　and　AMD.　Spline　smoothing　and　threshold　effects　were　applied　to　explore　non-linear　correlations.　Subgroup　analyses　were　performed　to　identify　underlying　covariates　affecting　this　relationship.　In　addition,　receiver　operating　characteristic　(ROC)　curve　analysis　was　used　to　evaluate　the　predictive　power　of　the　WWI　for　AMD.　Results　A　total　of　5,132　participants　were　enrolled　in　this　study.　The　results　showed　a　significant　positive　association　between　the　WWI　and　risk　of　AMD　(OR　=　1.76　(1.52,　2.04);　p　＜　0.0001).　When　the　WWI　was　categorized　into　tertiles,　the　highest　group　exhibited　a　stronger　association　compared　to　the　lowest　tertile　(OR　=　2.90　(2.18,　3.86);　p　＜　0.0001)　in　model　1.　The　subgroup　analyses　and　interaction　tests　indicated　that　the　relationship　between　the　WWI　and　AMD　was　stable　across　various　populations.　The　spline　smoothing　and　threshold　effects　showed　a　positive　non-linear　correlation　between　the　WWI　and　AMD　incidence.　Furthermore,　compared　to　body　mass　index　(BMI),　WC,　and　weight,　the　WWI　showed　better　predictability　for　AMD,　as　shown　by　the　ROC　analysis.　Conclusion　There　exists　a　positive　non-linear　association　between　the　WWI　and　AMD　in　US　adults　aged　40　years　and　older.　The　WWI-related　obesity　management　is　necessary　for　the　prevention　and　treatment　of　AMD.