Multifunctional　flexible　devices,　with　their　remarkable　skin　conformability,　biocompatibility,　and　adhesion,　have　extensive　applications　in　healthcare.　They　hold　significant　promise　in　reshaping　the　traditional　hospital-centric　healthcare　system　by　enabling　enhanced　physiological　signal　monitoring　and　biological　diagnostics.　This　review　provides　an　up-to-date　overview　of　these　devices,　focusing　on　classifications,　performances,　and　applications　while　also　addressing　existing　challenges　and　future　directions.　The　classification　system　is　detailed　based　on　conductive　materials　and　structural　designs.　Performance　analysis　involves　evaluating　optimal　device　functionalities,　emphasizing　mechanisms　and　typical　examples.　The　diverse　applications　of　these　devices　in　healthcare　span　the　acquisition,　analysis,　and　comprehensive　monitoring　of　electrophysiological,　biophysical,　and　biochemical　signals.　These　signals　also　play　a　crucial　role　in　clinical　therapy　through　integrated　diagnosis　and　treatment　devices.　The　review　concludes　by　outlining　primary　challenges　and　future　development　pathways,　highlighting　the　need　for　continued　research　and　innovation　in　this　burgeoning　field.　©　2025　Elsevier　Ltd