The　microstructure　of　commercially　pure　titanium　subjected　to　uniaxial　compression　was　meticulously　analyzed　using　electron　backscattered　diffraction　(EBSD)　to　investigate　the　variant　activation　behavior　of　{11−22}　twins　and　{10−12}　twins.　The　results　reveal　that　the　type　and　number　of　activated　twin　variants　are　strongly　dependent　on　the　loading　direction—whether　applied　along　the　normal　direction　(ND)　or　the　rolling　direction　(RD).　Notably,　loading　along　ND　can　activate　up　to　five　twin　variants,　and　most　are　activated　with　low　Schmid　Factor　(SF)　rank　but　high　SF　value.　The　variation　in　the　number　of　activated　twin　variants　within　a　grain　is　influenced　by　factors　such　as　grain　size,　the　activation　stress　of　twinning　versus　slip,　and　the　orientation　of　the　loading　direction　relative　to　the　c-axis.　SF　value　for　two　twinning　systems　({11−22}　twins　and　{10−12}　twins)　were　systematically　calculated　in　pure　titanium　as　a　function　of　the　angle　between　the　c-axis　and　the　loading　direction,　which　indicates　that　compression　along　a　direction　closely　aligned　with　the　c-axis　has　the　potential　to　activate　up　to　six　variants　of　{11−22}　twins　simultaneously.　In　contrast,　compression　perpendicular　to　the　c-axis　tends　to　activate　fewer　{10−12}　twin　variants,　with　the　twinning　activation　being　highly　sensitive　to　the　degree　of　c-axis　rotation.　©　2025　Elsevier　B.V.