Tetracycline　hydrochloride　has　emerged　as　a　potential　threat　in　water　pollution　treatment　due　to　its　widespread　use　as　a　common　antibiotic.　Fe-S-CMF　catalysts　were　prepared　via　one-step　pyrolysis　using　carbon　monolithic　foam　as　the　carrier　in　this　study.　The　addition　of　thiourea　strengthened　the　stability　of　the　carbon　skeleton　to　some　extent.　XRD,　Raman,　SEM,　TEM,　and　XPS　techniques　were　employed　to　characterize　the　physicochemical　properties　of　Fe-S-CMF,　further　confirming　its　successful　preparation.　The　influence　of　catalyst　doping　amount,　temperature,　pH,　anions,　and　other　factors　on　the　TC　degradation　was　investigated.　The　degradation　rate　of　tetracycline　reached　82.1　%,　which　was　attributed　to　free　radical　pathways　(SO4•-,　•OH)　and　non-free　radical　pathways　(1O2)　under　optimal　conditions.　The　ion　leaching　of　Fe-S-CMF　catalysts　was　detected,　with　iron　ion　leaching　maintained　at　a　relatively　low　level.　Moreover,　the　degradation　pathways　of　TC　were　deduced　based　on　the　results　of　LC-MS.　Additionally,　the　phytotoxicity　test　showed　that　the　toxicity　of　the　degradation　solution　was　much　lower　than　that　of　the　initial　solution.　Therefore,　the　Fe-S-CMF　catalyst　exhibits　good　catalytic　activity　and　facile　recycling,　providing　an　effective　method　with　excellent　PMS　activation　for　practical　wastewater　treatment　applications.　©　2025　Elsevier　Ltd