Landfill　leachate　contains　high　concentrations　of　hazardous　pollutants　that　require　effective　treatment　before　discharge.　Membrane　distillation　(MD)　has　emerged　as　a　promising　approach　for　leachate　treatment,　but　membrane　fouling　remains　a　major　challenge　for　its　practical　application.　This　study　introduces　an　innovative　in　situ　catalytic　MD　membrane　to　improve　antifouling　performance.　The　MnO2-doped　polyvinylidene　fluoride　(M-PVDF)　membrane　was　prepared　via　electrospinning,　incorporating　an　optimized　amount　of　MnO2　and　fluoroalkyl　modifier.　The　M-PVDF　membrane　demonstrated　excellent　retention　of　landfill　leachate　pollutants　across　all　test　cycles,　achieving　retention　rates　above　99.23%　for　non-ammonia　foulants.　No　membrane　wetting　was　observed　in　M-PVDF　during　the　cyclic　tests,　whereas　conventional　PVDF　membranes　exhibited　wetting　in　the　third　cycle.　The　fouled　M-PVDF　membrane　was　effectively　restored　after　cleaning　with　H2O2,　regaining　its　original　flux　and　demonstrating　robust　self-cleaning　capabilities.　This　performance　is　attributed　to　the　synergistic　effects　of　micro-nano　bubbles　and　MnO2-catalyzed　H2O2　free　radicals.　The　proposed　in　situ　catalytic　self-cleaning　strategy　significantly　enhances　the　antifouling　properties　of　MD,　providing　a　sustainable　solution　for　high-salinity　wastewater　treatment.　©　2025　The　Royal　Society　of　Chemistry.