Preparing　multi-color　and　multi-stimuli-responsive　circularly　polarized　luminescence　(CPL)　materials　and　understanding　the　evolution　of　chirality　through　the　visualized　mode　is　still　a　challenge.　Here,　an　encapsulation　engineering　approach　of　chiral　metal-organic　frameworks　(MOFs)　is　proposed　to　confine　guest　emitters　to　realize　multi-color　and　multi-stimuli-responsive　CPL.　Based　on　triplet-triplet　energy　transfer　(TTET),　white　CPL　and　near-infrared　circularly　polarized　room　temperature　phosphorescence　(NIR-CPRTP)　can　be　obtained　by　introducing　the　pyrene　derivatives.　With　the　introduction　of　the　guest　containing　vinylpyrene　group,　the　light-　and　thermal-responsive　CPL　with　the　signal　inversion　can　be　realized　through　the　reversible　[2+2]　cycloaddition　reaction　between　the　ligand　and　guest　triggered　by　visible　light/ultraviolet　light　or　heating.　Furthermore,　the　excitation-dependent　CPL　is　successfully　achieved　with　the　incorporation　of　excited　state　intramolecular　proton　transfer　(ESIPT)　molecules　into　nanopores.　Importantly,　the　chirality　magnification　can　be　greatly　enhanced　through　the　chiral　spatial　confinement,　the　accurate　host-guest　single　crystal　structures　of　FLT@DCF-12　and　FLT@LCF-12　provide　the　visualized　mode　to　understand　the　mechanism　of　chirality　transfer,　amplification　and　responsiveness.　White　LED　and　multiple　information　display　and　encryption　are　further　demonstrated.　This　breakthrough　provides　a　new　perspective　to　guest-encapsulated　chiral　MOFs　and　contributes　to　the　construction　of　stimuli-responsive　CPL-active　materials.　©　2025　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.