Given　the　inherent　limitations　of　current　nano-based　antimicrobial　materials,　including　their　restricted　broad-spectrum　efficacy　and　challenges　in　practical　application,　it　is　essential　to　develop　an　innovative　therapeutic　platform　that　effectively　alleviates　these　shortcomings.　Herein,　inspired　by　the　cryptic　antimicrobial　properties　of　natural　marine　mussels,　an　o-dihydroxybenzene-based　covalent　organic　framework　(TAPT-2,3DHA-COF)　is　successfully　synthesized,　which　exhibits　potent　broad-spectrum　antibacterial　activity　through　the　auto-oxidative　release　of　antibacterial　agents.　At　the　minimum　inhibitory　concentrations　(MICs),　potent　antibacterial　effects　(＞　90%　inhibition)　are　observed　against　six　common　and　even　resistant　bacterial　strains,　including　Staphylococcus　aureus　(1024　mu　g　mL(-1)),　Escherichia　coli　(512　mu　g　mL(-1)),　Pseudomonas　aeruginosa　(256　mu　g　mL(-1)),　methicillin-resistant　Staphylococcus　aureus　(MRSA;　1024　mu　g　mL(-1)),　etc.　Encouraged　by　the　aforementioned　excellent　performance,　a　hybrid　acrylamide　hydrogel　covalent　organic　framework　(Gel@COF)　is　constructed,　which　combines　the　advantages　of　both　components,　including　robust　antibacterial　activity,　mechanical　stability,　and　biocompatibility.　Notably,　the　potent　healing-promoting　capability　of　Gel@COF　is　demonstrated　in　diabetic　mice　models　with　MRSA-infected　wounds,　achieving　an　impressive　wound　healing　rate　of　99.62%.　This　work　not　only　broadens　the　application　of　COFs　in　the　field　of　antimicrobials　but　also　provides　a　new　strategy　for　developing　advanced　anti-infective　materials　in　the　future.