Co-based　catalysts　are　emerging　as　one　of　the　most　promising　catalysts　for　propane　dehydrogenation　(PDH)　due　to　their　abundant　availability,　environmental　friendliness,　and　efficient　activation　of　the　C-H　bond.　Isolated　Co　(II)　is　recognized　as　the　active　site　for　activating　the　C-H　bond　in　PDH;　however,　the　controllable　synthesis　of　Co　catalysts　with　well-defined　isolated　Co(II)　remains　a　challenge.　In　this　study,　a　direct　and　straightforward　route　was　developed　for　the　synthesis　of　Co-Beta　using　a　fluorine-assisted　hydrothermal　crystallization　method.　The　structure　of　Co-Beta　was　studied　using　various　characterization　tools,　including　XRD,　STEM,　H2-TPR,　UV-vis,　XPS,　solid-state　29Si　MAS　NMR　and　EXAFS　techniques.　It　was　confirmed　that　the　Co　species　are　incorporated　into　the　structure　of　Beta　zeolite,　existing　as　isolated　Co(II)　sites　embedded　within　the　framework　of　Beta　zeolite.　The　optimized　catalyst,　1.0Co-Beta,　exhibits　excellent　performance　in　PDH,　achieving　a　propane　conversion　of　approximately　50　%　and　propylene　selectivity　of　around　96　%　at　600　degrees　C.　This　performance　surpasses　that　of　previously　reported　non-noble　metal　catalysts.　This　study　provides　fundamental　insights　on　the　design　and　synthesis　of　highly　dispersed　metal　oxide　catalysts　for　PDH.