Background　The　differences　in　the　epidemiology,　clinical　characteristics,　and　treatment　strategies　between　primary　lymphoma　of　the　female　reproductive　tract　(PLFGT)　and　primary　lymphoma　of　the　male　reproductive　tract　(PLMGT)　remain　unclear.Materials　and　Methods　A　retrospective　analysis　of　PLFGT　and　PLMGT　data　from　the　surveillance,　epidemiology,　and　end　results　database　spanning　2000　to　2021　was　conducted　to　compare　the　differences　in　incidence　rates　and　clinical　indicators.　Bar　chart　analysis　highlighted　the　distribution　differences　between　lymphoma　subgroups.　Multivariate　Cox　regression　models　were　used　to　identify　prognostic　factors.　Kaplan-Meier　analysis　was　performed　to　evaluate　prognostic　survival　outcomes.Results　Data　from　724　patients　with　PLFGT　and　2025　with　PLMGT　were　analyzed,　with　diffuse　large　B-cell　lymphoma　(DLBCL)　being　the　most　prevalent　subtype.　The　incidence　of　PLFGT　was　higher　than　that　of　PLMGT;　however,　the　incidence　rates　in　both　groups　decreased.　Among　DLBCL　cases,　the　testis　was　the　most　frequent　primary　site　in　men,　whereas　the　ovary　predominated　in　women　with　follicular　lymphoma.　The　prognostic　risk　factors　for　PLFGT　included　age,　pathological　type,　primary　site,　surgery,　and　chemotherapy,　whereas　those　for　PLMGT　include　age,　pathological　type,　chemotherapy,　and　radiation.　In　the　DLBCL　subtype　of　PLFGT　in　the　study,　combined　chemotherapy　and　radiation　reportedly　enhance　cancer-specific　survival　in　patients　in　a　limited　stage　(Ann　Arbor　stage　I　and　II).　In　contrast,　for　patients　with　an　advanced　stage　(Ann　Arbor　stage　III　and　IV),　combined　chemotherapy　and　surgery　yielded　the　most　favorable　survival　outcomes.　In　the　DLBCL　subtype　of　PLMGT,　combined　chemotherapy,　radiation,　and　surgery　demonstrated　the　most　effective　therapeutic　outcomes　across　both　the　limited　and　advanced　stages.Conclusions　Clinical　differences　were　observed　between　PLFGT　and　PLMGT.　Prompt　and　accurate　identification　of　risk　factors　and　implementing　integrated　treatment　strategies　are　essential　for　optimizing　patient　outcomes.