The　fluid-structure　interaction　(FSI)　effects　existing　in　air-supported　membrane　roofs　subjected　to　wind　loading　are　significant,　which　would　result　in　the　vortex-induced　resonance.　This　study　employs　the　particle　image　velocimetry　(PIV)　technique　to　systematically　explore　the　FSI　mechanism　of　open-typed　hexagonal　inflatable　membrane　structures,　with　different　Reynolds　numbers　and　angles　of　attack　considered.　The　PIV　system　is　utilized　to　visualize　and　capture　the　surrounding　flow　field　characteristics,　including　vortex　separation,　turbulence　intensity,　and　eddy　structures.　Simultaneously,　the　aeroelastic　responses　of　the　membrane　structure　are　comprehensively　analyzed　in　both　time　and　frequency　domains,　such　as　the　displacement　statistic,　vibration　frequency,　damping　ratio,　and　vibration　mode.　By　integrating　the　fluid　spatiotemporal　evolution　and　structural　dynamics,　it　is　indicated　that　the　angle　of　attack　plays　a　pivotal　role　in　FSI　effects.　It　is　indicated　that　as　the　angle　of　attack　increases,　the　position　of　vortex　separation　shifts　from　the　trailing　edge　to　the　leading　edge　of　the　membrane　surface.　This　trend　would　enhance　the　FSI　effect　and　trigger　the　vortex-induced　vibration　(VIV).　In　the　case　of　large　angle　of　attack　(20　degrees)　and　Reynolds　number　(4.55　x105),　the　vortex　structure　develops　more　sufficiently,　with　its　diameter　enlarged　and　quantity　increased　significantly.　The　VIV　phenomenon　can　be　observed　on　the　leeward　side　of　the　membrane　when　the　reduced　wind　speed　is　close　to　1.95,　characterized　by　an　obvious　amplitude　jump,　a　sharp　reduction　of　damping　ratios,　and　frequency　lock-in.