The　development　of　low-cost　and　stable　monolithic　catalysts　remains　a　challenging　task,　particularly　in　achieving　uniform　active　components　distribution　and　preventing　shedding　of　active　components.　To　address　these,　this　work　proposes　the　preparation　of　monolithic　catalysts　using　manganese　slag　and　bauxite　as　raw　materials　by　phase　inversion　and　high　temperature　calcination　methods.　The　catalytic　performance　of　monolithic　catalyst　is　significantly　influenced　by　calcination　temperature　and　composition　ratios.　Amongst,　AM2-550　displays　the　best　catalytic　activity,　achieving　90　%　acetone　conversion　at　279　degrees　C　and　it　also　exhibits　excellent　long-term　stability　at　both　240　degrees　C　and　300　degrees　C.　The　superior　catalytic　performance　and　durability　of　AM2-550　are　attributed　to　its　weaker　Mn-O　bond　strength,　higher　acetone　adsorption　ability　and　abundant　Fe3+,　Mn3+　and　Oads.　Moreover,　the　findings　of　in　situ　DRIFTS　and　PTR-MS　reveal　the　acetone　reaction　pathway　of　AM2-T　catalysts,　demonstrating　that　the　decomposition　of　acetic　acid　serves　as　the　rate-limiting　step　during　acetone　oxidation.　This　work　sheds　new　insights　into　the　design　of　cost-effective　monolithic　catalysts　based　on　the　solid　waste　materials.