To　overcome　the　challenges　associated　with　conventional　ultraviolet-C　(UV-C)　light-emitting　devices—such　as　toxic　mercury,　aging　of　organic　adhesives,　and　various　stability　concerns—an　efficient　UV-C　emitting　nano-glass　composite　(nano-GC)　has　been　developed.　The　transparent　nano-GCs　embedded　with　Pr3+-doped　Li(Al7B4O17)　nanocrystals　(NCs),　achieved　through　precise　modulation　of　the　fluoride　content　in　the　glass　matrix　network.　The　unique　architecture　of　these　nano-GCs　synergistically　combines　the　high　luminescence　efficiency　characteristic　of　a　crystalline　phase　with　the　robustness　of　glass.　Upon　excitation　by　deep-UV,　X-ray　and　high　energy　electron-beams,　the　nano-GCs　exhibit　pronounced　5d-4f　interconfigurational　emissions　of　Pr3+,　with　their　emission　profile　closely　aligning　with　the　germicidal　effectiveness　curve.　Although　the　transmittance　of　nano-GCs　is　reduced　compared　to　that　of　precursor　glass　(PG),　their　UV-C　luminescence　output　is　significantly　enhanced—e.g.,　a　sixfold　increase　under　e-beam　pumping.　These　nano-GCs　achieve　an　impressive　photoluminescence　quantum　yield　of　up　to　25.93%,　surpassing　most　previously　reported　Pr3+　doped　glasses　and　nano-GCs.　Moreover,　the　nano-GCs　exhibit　robust　X-ray　excited　luminescence,　with　an　intensity　more　than　twice　that　of　the　commercial　Bi4Ge3O12　(BGO)　crystal,　and　exhibit　a　highly　linear　response　to　X-ray　dose,　accompanied　by　a　decay　time　of　24.13　ns　under　γ-ray　excitation.　Collectively,　this　study　presents　a　novel　approach　to　the　development　of　disinfection　phosphors　and　fast　scintillators.　©　2025　The　Royal　Society　of　Chemistry.